Clinical Characteristics and Outcomes of Deep Vein Thrombosis in Relation to Location: A Retrospective Analysis Study
Background: Deep vein thrombosis (DVT) is a leading cause of death disability. DVT can be classified based on the location and extent of the clot into isolated distal DVT (iDDVT), isolated proximal DVT (iPDVT), or mixed DVT. The aim of this study is to explore the baseline characteristics and clinic...
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SAGE Publishing
2025-01-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296241313055 |
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| author | Majed S. Al Yami PharmD Abdulmajeed M. Alshehri PharmD Ghadah M. Alotaibi PharmD Mariam S. Alsulimani PharmD Fay M. Alotaibi PharmD Rawan A. Alotaibi PharmD Nouf A. Alqahtani PharmD Lama A. Alhumaidan PharmD Lubna S. Bin Hadhir PharmD Norah M. Alebrah PharmD Sumaya N. Almohareb PharmD Omar A. Alshaya PharmD Omar S. Alkhezi PharmD Osamah M. Alfayez PharmD Omar A. Almohammed PhD Amal M. Badawoud PhD |
| author_facet | Majed S. Al Yami PharmD Abdulmajeed M. Alshehri PharmD Ghadah M. Alotaibi PharmD Mariam S. Alsulimani PharmD Fay M. Alotaibi PharmD Rawan A. Alotaibi PharmD Nouf A. Alqahtani PharmD Lama A. Alhumaidan PharmD Lubna S. Bin Hadhir PharmD Norah M. Alebrah PharmD Sumaya N. Almohareb PharmD Omar A. Alshaya PharmD Omar S. Alkhezi PharmD Osamah M. Alfayez PharmD Omar A. Almohammed PhD Amal M. Badawoud PhD |
| author_sort | Majed S. Al Yami PharmD |
| collection | DOAJ |
| description | Background: Deep vein thrombosis (DVT) is a leading cause of death disability. DVT can be classified based on the location and extent of the clot into isolated distal DVT (iDDVT), isolated proximal DVT (iPDVT), or mixed DVT. The aim of this study is to explore the baseline characteristics and clinical outcomes of patients with different types of DVT. Methods: This was a retrospective study of patients who experienced their first DVT event and received an anticoagulant for management. The outcomes of this study include evaluating patients’ characteristics for patients with DVT and assessing the incidence of recurrent DVT, major bleeding (MB), VTE-related rehospitalization, and DVT-related inpatient mortality across different types of DVT. Results: A total of 493 patients were included in the study. Of those, 273 (55.4%) had iPDVT, 25 (5.1%) had iDDVT, and 195 (39.6%) had mixed DVT. The VTE etiology was similar across the groups except for the leg injury, which was significantly higher in patients with iDDVT (24%) compared to iPDVT (6.2%) and mixed DVT (5.6%) ( P = .002). At 12 months, a total of 49 patients (9.9%) had a recurrent DVT event; 25 (9.2%) in the iPDVT group, 3 (12.0%) in the iDDVT group, and 21 (10.8%) in the mixed DVT group ( P = .797). Rates of MB, re-hospitalization, and death from DVT were similar between the groups. Conclusion: Baseline characteristics were not significantly linked to the risk of developing a specific type of lower extremity DVT. Long-term outcomes were similar across all DVT types. |
| format | Article |
| id | doaj-art-4d4d919273144bdd927b615591975c32 |
| institution | Kabale University |
| issn | 1938-2723 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj-art-4d4d919273144bdd927b615591975c322025-01-09T11:03:55ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232025-01-013110.1177/10760296241313055Clinical Characteristics and Outcomes of Deep Vein Thrombosis in Relation to Location: A Retrospective Analysis StudyMajed S. Al Yami PharmD0Abdulmajeed M. Alshehri PharmD1Ghadah M. Alotaibi PharmD2Mariam S. Alsulimani PharmD3Fay M. Alotaibi PharmD4Rawan A. Alotaibi PharmD5Nouf A. Alqahtani PharmD6Lama A. Alhumaidan PharmD7Lubna S. Bin Hadhir PharmD8Norah M. Alebrah PharmD9Sumaya N. Almohareb PharmD10Omar A. Alshaya PharmD11Omar S. Alkhezi PharmD12Osamah M. Alfayez PharmD13Omar A. Almohammed PhD14Amal M. Badawoud PhD15 King Abdullah International Medical Research Center, Riyadh, Saudi Arabia King Abdullah International Medical Research Center, Riyadh, Saudi Arabia Department of Pharmacy Practice, College of Pharmacy, , Riyadh, Saudi Arabia Department of Pharmacy Practice, College of Pharmacy, , Riyadh, Saudi Arabia Department of Pharmacy Practice, College of Pharmacy, , Riyadh, Saudi Arabia Department of Pharmacy Practice, College of Pharmacy, , Riyadh, Saudi Arabia Department of Pharmacy Practice, College of Pharmacy, , Riyadh, Saudi Arabia Department of Pharmacy Practice, College of Pharmacy, , Riyadh, Saudi Arabia Department of Pharmacy Practice, College of Pharmacy, , Riyadh, Saudi Arabia Department of Pharmacy Practice, College of Pharmacy, , Riyadh, Saudi Arabia King Abdullah International Medical Research Center, Riyadh, Saudi Arabia King Abdullah International Medical Research Center, Riyadh, Saudi Arabia Department of Pharmacy Practice, College of Pharmacy, , Qassim, Saudi Arabia Department of Pharmacy Practice, College of Pharmacy, , Qassim, Saudi Arabia Pharmacoeconomics Research Unit, College of Pharmacy, , Riyadh, Saudi Arabia Department of Pharmacy Practice, College of Pharmacy, , Riyadh, Saudi ArabiaBackground: Deep vein thrombosis (DVT) is a leading cause of death disability. DVT can be classified based on the location and extent of the clot into isolated distal DVT (iDDVT), isolated proximal DVT (iPDVT), or mixed DVT. The aim of this study is to explore the baseline characteristics and clinical outcomes of patients with different types of DVT. Methods: This was a retrospective study of patients who experienced their first DVT event and received an anticoagulant for management. The outcomes of this study include evaluating patients’ characteristics for patients with DVT and assessing the incidence of recurrent DVT, major bleeding (MB), VTE-related rehospitalization, and DVT-related inpatient mortality across different types of DVT. Results: A total of 493 patients were included in the study. Of those, 273 (55.4%) had iPDVT, 25 (5.1%) had iDDVT, and 195 (39.6%) had mixed DVT. The VTE etiology was similar across the groups except for the leg injury, which was significantly higher in patients with iDDVT (24%) compared to iPDVT (6.2%) and mixed DVT (5.6%) ( P = .002). At 12 months, a total of 49 patients (9.9%) had a recurrent DVT event; 25 (9.2%) in the iPDVT group, 3 (12.0%) in the iDDVT group, and 21 (10.8%) in the mixed DVT group ( P = .797). Rates of MB, re-hospitalization, and death from DVT were similar between the groups. Conclusion: Baseline characteristics were not significantly linked to the risk of developing a specific type of lower extremity DVT. Long-term outcomes were similar across all DVT types.https://doi.org/10.1177/10760296241313055 |
| spellingShingle | Majed S. Al Yami PharmD Abdulmajeed M. Alshehri PharmD Ghadah M. Alotaibi PharmD Mariam S. Alsulimani PharmD Fay M. Alotaibi PharmD Rawan A. Alotaibi PharmD Nouf A. Alqahtani PharmD Lama A. Alhumaidan PharmD Lubna S. Bin Hadhir PharmD Norah M. Alebrah PharmD Sumaya N. Almohareb PharmD Omar A. Alshaya PharmD Omar S. Alkhezi PharmD Osamah M. Alfayez PharmD Omar A. Almohammed PhD Amal M. Badawoud PhD Clinical Characteristics and Outcomes of Deep Vein Thrombosis in Relation to Location: A Retrospective Analysis Study Clinical and Applied Thrombosis/Hemostasis |
| title | Clinical Characteristics and Outcomes of Deep Vein Thrombosis in Relation to Location: A Retrospective Analysis Study |
| title_full | Clinical Characteristics and Outcomes of Deep Vein Thrombosis in Relation to Location: A Retrospective Analysis Study |
| title_fullStr | Clinical Characteristics and Outcomes of Deep Vein Thrombosis in Relation to Location: A Retrospective Analysis Study |
| title_full_unstemmed | Clinical Characteristics and Outcomes of Deep Vein Thrombosis in Relation to Location: A Retrospective Analysis Study |
| title_short | Clinical Characteristics and Outcomes of Deep Vein Thrombosis in Relation to Location: A Retrospective Analysis Study |
| title_sort | clinical characteristics and outcomes of deep vein thrombosis in relation to location a retrospective analysis study |
| url | https://doi.org/10.1177/10760296241313055 |
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