Alternative production of pro-death Bax∆2 protein via ribosomal frameshift in Alzheimer’s disease

Alternative production of pro-death Bax∆2 protein via ribosomal frameshift in Alzheimer’s disease

Abstract Pro-death Bax family member, Bax∆2, forms protein aggregates in Alzheimer’s disease neurons and causes stress granule-mediated neuronal death. Production of Bax∆2 originated from two events: alternative splicing of Bax exon 2 and a microsatellite mutation (a deletion from poly guanines, G8...

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Bibliographic Details
Main Authors: Qi Yao, Adriana Mañas, Evan Beatty, Anne Caroline Mascarenhas dos Santos, Yi Zhou, Oscar Juárez, Hui Chen, Jialing Xiang
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Bax
Bax∆2
Cell death
Ribosomal frameshift
Alzheimer’s disease
Microsatellite
Online Access:https://doi.org/10.1038/s41598-024-76061-1
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https://doi.org/10.1038/s41598-024-76061-1

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