Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment via ROS scavenging and YAP1 stabilization

Bimetallic clusterzymes-loaded dendritic mesoporous silica particle regulate arthritis microenvironment via ROS scavenging and YAP1 stabilization

Clusterzymes are synthetic enzymes exhibiting substantial catalytic activity and selectivity, which are uniquely driven by single-atom constructs. A dramatic increase in antioxidant capacity, 158 times more than natural trolox, is noted when single-atom copper is incorporated into gold-based cluster...

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Main Authors: Yang Jin, Chuan Hu, Jiechao Xia, Dingqi Xie, Lin Ye, Xinyi Ye, Li Jiang, Honghai Song, Yutao Zhu, Sicheng Jiang, Weiqing Li, Weiming Qi, Yannan Yang, Zhijun Hu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-12-01
Series:Bioactive Materials
Subjects:
Clusterzyme
Sustained delivery
Reactive oxygen species
Hippo pathway
Rabbit anterior cruciate ligament transection model
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24003918
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