Predicting ROS1 and ALK fusions in NSCLC from H&E slides with a two-step vision transformer approach

Predicting ROS1 and ALK fusions in NSCLC from H&E slides with a two-step vision transformer approach

Abstract Non-small cell lung cancer (NSCLC) is one of the deadliest and most prevalent cancers worldwide, with 5-year survival rates of ~28%. The molecular heterogeneity within NSCLC encompasses several types of genetic alterations, such as mutations, amplifications, and rearrangements, and can driv...

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Main Authors: Eghbal Amidi, Mohammadreza Ramzanpour, Ming Chen, Tommy Boucher, Mukund Varma, Timothy Samec, Brian Lamon, Nicolas Stransky, Mark R. Miglarese, Matthew Oberley, David Spetzler, George W. Sledge
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01037-x
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https://doi.org/10.1038/s41698-025-01037-x

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