The Impact of Conjugation Mode and Site on Tubulysin Antibody‐Drug‐Conjugate Efficacy and Stability

The Impact of Conjugation Mode and Site on Tubulysin Antibody‐Drug‐Conjugate Efficacy and Stability

Antibody‐drug conjugates (ADCs) represent a prominent class of biotherapeutics engineered to selectively deliver cytotoxic payloads to tumors, thereby facilitating targeted cell killing. While first‐generation ADCs, created by conjugating payloads to surface‐accessible lysine or hinge‐cysteine resid...

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Main Authors: Sayumi Yamazoe, Qinqin Cheng, Srikanth Kotapati, Vangipuram S. Rangan, Mei‐Chen Sung, Madhura Deshpande, Aarti Jashnani, Cong Qiang, Michael J. Smith, Chin Pan, Gavin Dollinger, Arvind Rajpal, Pavel Strop, Chetana Rao
Format: Article
Language:English
Published: Wiley-VCH 2025-08-01
Series:ChemistryOpen
Subjects:
antibody‐drug conjugates
deconjugation
payload metabolism
site‐specific conjugations
tubulysin
Online Access:https://doi.org/10.1002/open.202400522
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https://doi.org/10.1002/open.202400522

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