Extracellular vesicle-derived miR-146a as a novel crosstalk mechanism for high-fat induced atherosclerosis by targeting SMAD4

Extracellular vesicle-derived miR-146a as a novel crosstalk mechanism for high-fat induced atherosclerosis by targeting SMAD4

Introduction: Exosome-miR-146a is significantly increased in patients with Atherosclerosis (AS), but its mechanism and effect on AS have not been fully elucidated. Objectives: To explore the change rule and mechanism of exosomes release, and the role and molecular mechanism of exosome-miR-146a in AS...

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Main Authors: Kefeng Zhai, Liangle Deng, Yuxuan Wu, Han Li, Jing Zhou, Ying Shi, Jianhu Jia, Wei Wang, Sihui Nian, Ghulam Jilany Khan, Hesham R. El-Seedi, Hong Duan, Lili Li, Zhaojun Wei
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Advanced Research
Subjects:
exosome-miR-146a
SMAD4
Foam cells
Atherosclerosis
NMMHC II A
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224003552
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