In Situ Light-Source Delivery During 5-Aminulevulinic Acid-Guided High-Grade Glioma Resection: Spatial, Functional and Oncological Informed Surgery

In Situ Light-Source Delivery During 5-Aminulevulinic Acid-Guided High-Grade Glioma Resection: Spatial, Functional and Oncological Informed Surgery

Background/Objectives: 5-aminulevulinic acid (5-ALA)-guided surgery for high-grade gliomas remains a challenge in neuro-oncological surgery. Inconsistent fluorescence visualisation, subjective quantification and false negatives due to blood, haemostatic agents or optical impediments from the externa...

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Main Authors: José Pedro Lavrador, Francesco Marchi, Ali Elhag, Nida Kalyal, Engelbert Mthunzi, Mariam Awan, Oliver Wroe-Wright, Alba Díaz-Baamonde, Ana Mirallave-Pescador, Zita Reisz, Richard Gullan, Francesco Vergani, Keyoumars Ashkan, Ranjeev Bhangoo
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomedicines
Subjects:
5-ALA
blue-light source
glioblastoma
surgery
Spectra
MIPS
Online Access:https://www.mdpi.com/2227-9059/12/12/2748
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