The functions and applications of organoids in rheumatic immune diseases
Rheumatic immune disorders are a group of conditions that affect the immune system, leading to various clinical symptoms. These diseases can cause pain, reduce the quality of life, and increase the risk of death in severe cases. Diagnosis and treatment are very complex due to the different types of...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-06-01
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| Series: | Journal of Holistic Integrative Pharmacy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2707368824000335 |
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| _version_ | 1846170007621337088 |
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| author | Huaijuan Huang Aimin Yan Hesong Wang Heng Xu Ruhang Li Kai Yuan Guangrui Huang |
| author_facet | Huaijuan Huang Aimin Yan Hesong Wang Heng Xu Ruhang Li Kai Yuan Guangrui Huang |
| author_sort | Huaijuan Huang |
| collection | DOAJ |
| description | Rheumatic immune disorders are a group of conditions that affect the immune system, leading to various clinical symptoms. These diseases can cause pain, reduce the quality of life, and increase the risk of death in severe cases. Diagnosis and treatment are very complex due to the different types of disease and individual differences and the unknown pathogenesis of the disease. Further research is necessary to provide new clues for disease treatment. Organoid technology that makes up for the shortcomings of animal model species differences can better simulate disease onset mechanisms than animal models. It can be used as a screening platform for new therapeutic targets, as well as personalized settings based on patient-derived organoids, promising as an effective tool for the study of rheumatic immune diseases. Therefore, the article summarizes studies related to organoids and their application in rheumatic immune diseases. It also provides an outlook on the potential of organoids in this field and discusses the challenges that need to be addressed, putting new ideas for future research on these diseases. |
| format | Article |
| id | doaj-art-4c758e91c3be49b2a3fc7d4a23b4fff6 |
| institution | Kabale University |
| issn | 2707-3688 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Journal of Holistic Integrative Pharmacy |
| spelling | doaj-art-4c758e91c3be49b2a3fc7d4a23b4fff62024-11-12T05:21:49ZengKeAi Communications Co., Ltd.Journal of Holistic Integrative Pharmacy2707-36882024-06-0152141147The functions and applications of organoids in rheumatic immune diseasesHuaijuan Huang0Aimin Yan1Hesong Wang2Heng Xu3Ruhang Li4Kai Yuan5Guangrui Huang6School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, ChinaSchool of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, ChinaCorresponding author. School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, ChinaCorresponding author. School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, China.; School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 100029, ChinaRheumatic immune disorders are a group of conditions that affect the immune system, leading to various clinical symptoms. These diseases can cause pain, reduce the quality of life, and increase the risk of death in severe cases. Diagnosis and treatment are very complex due to the different types of disease and individual differences and the unknown pathogenesis of the disease. Further research is necessary to provide new clues for disease treatment. Organoid technology that makes up for the shortcomings of animal model species differences can better simulate disease onset mechanisms than animal models. It can be used as a screening platform for new therapeutic targets, as well as personalized settings based on patient-derived organoids, promising as an effective tool for the study of rheumatic immune diseases. Therefore, the article summarizes studies related to organoids and their application in rheumatic immune diseases. It also provides an outlook on the potential of organoids in this field and discusses the challenges that need to be addressed, putting new ideas for future research on these diseases.http://www.sciencedirect.com/science/article/pii/S2707368824000335OrganoidsRheumatic immune diseaseInduced pluripotent stem cells (iPSC) |
| spellingShingle | Huaijuan Huang Aimin Yan Hesong Wang Heng Xu Ruhang Li Kai Yuan Guangrui Huang The functions and applications of organoids in rheumatic immune diseases Journal of Holistic Integrative Pharmacy Organoids Rheumatic immune disease Induced pluripotent stem cells (iPSC) |
| title | The functions and applications of organoids in rheumatic immune diseases |
| title_full | The functions and applications of organoids in rheumatic immune diseases |
| title_fullStr | The functions and applications of organoids in rheumatic immune diseases |
| title_full_unstemmed | The functions and applications of organoids in rheumatic immune diseases |
| title_short | The functions and applications of organoids in rheumatic immune diseases |
| title_sort | functions and applications of organoids in rheumatic immune diseases |
| topic | Organoids Rheumatic immune disease Induced pluripotent stem cells (iPSC) |
| url | http://www.sciencedirect.com/science/article/pii/S2707368824000335 |
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