Copy number normalization distinguishes differential signals driven by copy number differences in ATAC-seq and ChIP-seq

Copy number normalization distinguishes differential signals driven by copy number differences in ATAC-seq and ChIP-seq

Abstract A common objective across ATAC-seq and ChIP-seq analyses is to identify differential signals across contrasted conditions. However, in differential analyses, the impact of copy number variation is often overlooked. Here, we demonstrated copy number differences among samples could drive, if...

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Bibliographic Details
Main Authors: Dingwen Su, Moritz Peters, Volker Soltys, Yingguang Frank Chan
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Genomics
Subjects:
ATAC-seq
ChIP-seq
Copy number variation
Aneuploidy
Copy number normalization
Differential analysis
Online Access:https://doi.org/10.1186/s12864-025-11442-y
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https://doi.org/10.1186/s12864-025-11442-y

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