Influence of Excipients and Pressing Force on the Impurity Content of N-(4-aminobenzoyl)-L-glutamic Acid in Folic Acid Drugs During Storage

Influence of Excipients and Pressing Force on the Impurity Content of N-(4-aminobenzoyl)-L-glutamic Acid in Folic Acid Drugs During Storage

Introduction. Excipients, impurities contained in them, and sorbed water are one of the reasons for degradation of the active pharmaceutical substance (API). Excipients effect should be especially evaluated for moisture-sensitive APIs. Folic acid (FA) is an important vitamin for humans. It hydrolyze...

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Bibliographic Details
Main Authors: N. A. Obraztsova, A. A. Samsonov, M. A. Kovtunenko, V. N. Shmeleva, N. A. Golubeva
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2023-05-01
Series:Разработка и регистрация лекарственных средств
Subjects:
folic acid
excipients
hydrolysis
lactose
pressing force
impurity
Online Access:https://www.pharmjournal.ru/jour/article/view/1482
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https://www.pharmjournal.ru/jour/article/view/1482

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