Effect of 1918 PB1-F2 expression on influenza A virus infection kinetics.

Relatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication, increases apoptosis in monocytes, alters viral po...

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Bibliographic Details
Main Authors: Amber M Smith, Frederick R Adler, Julie L McAuley, Ryan N Gutenkunst, Ruy M Ribeiro, Jonathan A McCullers, Alan S Perelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001081&type=printable
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