Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice

Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice

Abstract In anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and systemic lupus erythematosus (SLE), glomerulonephritis is a severe kidney complication driven by immune cells, including T cells. However, the mechanisms underlying T cell activation in these contexts remain elusive. He...

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Main Authors: Huiying Wang, Jonas Engesser, Robin Khatri, Darius P. Schaub, Hans-Joachim Paust, Zeba Sultana, Saskia-Larissa Jauch-Speer, Anett Peters, Anna Kaffke, Stefan Bonn, Tobias B. Huber, Hans-Willi Mittrücker, Christian F. Krebs, Ulf Panzer, Nariaki Asada
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59819-7
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https://doi.org/10.1038/s41467-025-59819-7

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