Generation of four human-derived iPSC TorsinA-3xFLAG reporter lines from a DYT-TOR1A patient

Generation of four human-derived iPSC TorsinA-3xFLAG reporter lines from a DYT-TOR1A patient

A 3-bp deletion (ΔGAG) in TOR1A is a common cause of early-onset isolated dystonia DYT-TOR1A. The exact disease mechanism remains unknown. Here we describe the generation and characterization of four TorsinA-3xFLAG reporter induced pluripotent cell (iPSC) lines derived from a DYT-TOR1A patient. The...

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Bibliographic Details
Main Authors: Kerstin Tanzer, Britta Meier, Franca Vulinovic, Heike Pawlack, Christine Klein, Philip Seibler, Aleksandar Rakovic
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Stem Cell Research
Subjects:
DYT-TOR1A
TorsinA
CRISPR-Cas9
iPSC
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506124002939
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http://www.sciencedirect.com/science/article/pii/S1873506124002939

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