Longitudinal circulating tumor DNA analysis during treatment of locally advanced resectable gastric or gastroesophageal junction adenocarcinoma: the PLAGAST prospective biomarker study

Longitudinal circulating tumor DNA analysis during treatment of locally advanced resectable gastric or gastroesophageal junction adenocarcinoma: the PLAGAST prospective biomarker study

Abstract Patients with locally advanced resectable (LAR) gastric/gastroesophageal junction (G/GEJ) adenocarcinomas have a high recurrence risk despite pre- and post-operative treatment. In the PLAGAST prospective study (NCT02674373), we investigated the ability of circulating tumor DNA (ctDNA) to pr...

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Main Authors: Aziz Zaanan, Audrey Didelot, Chloé Broudin, George Laliotis, Erik Spickard, Punashi Dutta, Aurélien Saltel-Fulero, Francesco Giulio Sullo, Margot Pizzamiglio, Antoine Mariani, Widad Lahlou, Meenakshi Malhotra, Shruti Sharma, Himanshu Sethi, Adham Jurdi, Minetta C. Liu, Pierre Laurent-Puig
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62056-7
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