Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine

Metformin attenuates central sensitization by regulating neuroinflammation through the TREM2-SYK signaling pathway in a mouse model of chronic migraine

Abstract Background Chronic migraine (CM) is a serious neurological disorder. Central sensitization is one of the important pathophysiological mechanisms underlying CM, and microglia-induced neuroinflammation conduces to central sensitization. Triggering receptor expressed on myeloid cells 2 (TREM2)...

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Bibliographic Details
Main Authors: Zhenzhen Fan, Dandan Su, Zi Chao Li, Songtang Sun, Zhaoming Ge
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Neuroinflammation
Subjects:
Metformin
Microglia
TREM2
Chronic migraine
SYK
Central sensitization
Online Access:https://doi.org/10.1186/s12974-024-03313-2
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https://doi.org/10.1186/s12974-024-03313-2

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