Peroxisomal lipid metabolism inhibits Pimozide-induced cancer cell death by regulating ATP homeostasis

Abstract Antipsychotic drugs have been shown to suppress tumor growth and induce cell death, but their clinical application remains limited. Pimozide, an FDA-approved antipsychotic, holds significant potential for cancer treatment. However, the mechanisms underlying tumor cell responses to Pimozide...

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Bibliographic Details
Main Authors: Zihang Pan, Fazhi Yu, Weiyi You, Feng Li, Fengjuan Cui, Jing Guo, Zhenye Yang
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-025-00575-0
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