Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation
Background: Asthma and depression frequently co-occur, potentially worsening each other’s symptoms. The salience network (SN) may play a key role in this link, but the roles of the default mode network (DMN) and frontoparietal network (FPN), as outlined in the triple network theory, remain unclear i...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Biological Psychiatry Global Open Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667174325000813 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849331334167658496 |
|---|---|
| author | Maxie Liebscher Claire Laubacher Theodore P. Imhoff-Smith Rasmus M. Birn Danika R. Klaus Corrina J. Frye William W. Busse Melissa A. Rosenkranz |
| author_facet | Maxie Liebscher Claire Laubacher Theodore P. Imhoff-Smith Rasmus M. Birn Danika R. Klaus Corrina J. Frye William W. Busse Melissa A. Rosenkranz |
| author_sort | Maxie Liebscher |
| collection | DOAJ |
| description | Background: Asthma and depression frequently co-occur, potentially worsening each other’s symptoms. The salience network (SN) may play a key role in this link, but the roles of the default mode network (DMN) and frontoparietal network (FPN), as outlined in the triple network theory, remain unclear in the asthma-depression connection. This longitudinal study investigated pre-post changes in graph-theory metrics within and between the 3 networks in individuals with asthma and how these relate to depressive symptoms. Methods: Twenty-four individuals with asthma underwent functional magnetic resonance imaging scans pre- and postsegmental allergen challenge. Depressive symptoms were assessed at baseline using the Beck Depression Inventory. Changes in graph-theory metrics were analyzed using region-of-interest (ROI)-to-ROI analyses, controlling for sex. Results: Allergen challenge led to changes in network properties. Within-network analyses showed decreased degree centrality (β = 0.50, false discovery rate–corrected p [pFDR] = .004) and betweenness centrality (β = 0.10, pFDR = .025) of the posterior cingulate cortex (DMN) and reduced degree centrality of the anterior cingulate cortex (SN), which correlated with depressive symptoms (β = 0.05, pFDR = .017). Between-network analyses showed reduced closeness centrality in the bilateral lateral parietal during SN-DMN interactions (right: β = 0.23, pFDR = .010; left: β = 0.23, pFDR = .013) and increased degree centrality in the left posterior parietal cortex during SN-FPN interactions (β = −0.10, pFDR = .038), which correlated with depressive symptoms. Conclusions: Allergen challenge alters graph-theory metrics within and between resting-state networks, with changes linked to depression symptoms. Findings highlight the SN’s critical role in network switching and its vulnerability to inflammation in asthma-depression connection. |
| format | Article |
| id | doaj-art-49e567d6e29e4394b4550fc42a28ae80 |
| institution | Kabale University |
| issn | 2667-1743 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biological Psychiatry Global Open Science |
| spelling | doaj-art-49e567d6e29e4394b4550fc42a28ae802025-08-20T03:46:38ZengElsevierBiological Psychiatry Global Open Science2667-17432025-09-015510052710.1016/j.bpsgos.2025.100527Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway InflammationMaxie Liebscher0Claire Laubacher1Theodore P. Imhoff-Smith2Rasmus M. Birn3Danika R. Klaus4Corrina J. Frye5William W. Busse6Melissa A. Rosenkranz7Center for Healthy Minds, University of Wisconsin-Madison, Madison, Wisconsin; German Center for Neurodegenerative Diseases, Dresden, GermanyCenter for Healthy Minds, University of Wisconsin-Madison, Madison, WisconsinDepartment of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WisconsinDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WisconsinDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WisconsinWaisman Center, University of Wisconsin-Madison, Madison, WisconsinDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WisconsinCenter for Healthy Minds, University of Wisconsin-Madison, Madison, Wisconsin; Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin; Address correspondence to Melissa A. Rosenkranz, Ph.D.Background: Asthma and depression frequently co-occur, potentially worsening each other’s symptoms. The salience network (SN) may play a key role in this link, but the roles of the default mode network (DMN) and frontoparietal network (FPN), as outlined in the triple network theory, remain unclear in the asthma-depression connection. This longitudinal study investigated pre-post changes in graph-theory metrics within and between the 3 networks in individuals with asthma and how these relate to depressive symptoms. Methods: Twenty-four individuals with asthma underwent functional magnetic resonance imaging scans pre- and postsegmental allergen challenge. Depressive symptoms were assessed at baseline using the Beck Depression Inventory. Changes in graph-theory metrics were analyzed using region-of-interest (ROI)-to-ROI analyses, controlling for sex. Results: Allergen challenge led to changes in network properties. Within-network analyses showed decreased degree centrality (β = 0.50, false discovery rate–corrected p [pFDR] = .004) and betweenness centrality (β = 0.10, pFDR = .025) of the posterior cingulate cortex (DMN) and reduced degree centrality of the anterior cingulate cortex (SN), which correlated with depressive symptoms (β = 0.05, pFDR = .017). Between-network analyses showed reduced closeness centrality in the bilateral lateral parietal during SN-DMN interactions (right: β = 0.23, pFDR = .010; left: β = 0.23, pFDR = .013) and increased degree centrality in the left posterior parietal cortex during SN-FPN interactions (β = −0.10, pFDR = .038), which correlated with depressive symptoms. Conclusions: Allergen challenge alters graph-theory metrics within and between resting-state networks, with changes linked to depression symptoms. Findings highlight the SN’s critical role in network switching and its vulnerability to inflammation in asthma-depression connection.http://www.sciencedirect.com/science/article/pii/S2667174325000813AsthmaDepressionfMRIGraph theoryInflammationTriple network theory |
| spellingShingle | Maxie Liebscher Claire Laubacher Theodore P. Imhoff-Smith Rasmus M. Birn Danika R. Klaus Corrina J. Frye William W. Busse Melissa A. Rosenkranz Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation Biological Psychiatry Global Open Science Asthma Depression fMRI Graph theory Inflammation Triple network theory |
| title | Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation |
| title_full | Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation |
| title_fullStr | Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation |
| title_full_unstemmed | Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation |
| title_short | Resting-State Network Dynamics in Asthma: Interplay Between Depressive Symptoms and Airway Inflammation |
| title_sort | resting state network dynamics in asthma interplay between depressive symptoms and airway inflammation |
| topic | Asthma Depression fMRI Graph theory Inflammation Triple network theory |
| url | http://www.sciencedirect.com/science/article/pii/S2667174325000813 |
| work_keys_str_mv | AT maxieliebscher restingstatenetworkdynamicsinasthmainterplaybetweendepressivesymptomsandairwayinflammation AT clairelaubacher restingstatenetworkdynamicsinasthmainterplaybetweendepressivesymptomsandairwayinflammation AT theodorepimhoffsmith restingstatenetworkdynamicsinasthmainterplaybetweendepressivesymptomsandairwayinflammation AT rasmusmbirn restingstatenetworkdynamicsinasthmainterplaybetweendepressivesymptomsandairwayinflammation AT danikarklaus restingstatenetworkdynamicsinasthmainterplaybetweendepressivesymptomsandairwayinflammation AT corrinajfrye restingstatenetworkdynamicsinasthmainterplaybetweendepressivesymptomsandairwayinflammation AT williamwbusse restingstatenetworkdynamicsinasthmainterplaybetweendepressivesymptomsandairwayinflammation AT melissaarosenkranz restingstatenetworkdynamicsinasthmainterplaybetweendepressivesymptomsandairwayinflammation |