Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD

Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD

Abstract Background Reduction of adult hippocampal neurogenesis is an early critical event in Alzheimer’s disease (AD), contributing to progressive memory loss and cognitive decline. Reduced levels of the nucleoporin 153 (Nup153), a key epigenetic regulator of NSC stemness, characterize the neural s...

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Main Authors: Claudia Colussi, Alessia Bertozzi, Lucia Leone, Marco Rinaudo, Raimondo Sollazzo, Federica Conte, Elena Paccosi, Luca Nardella, Giuseppe Aceto, Domenica Donatella Li Puma, Cristian Ripoli, Maria Gabriella Vita, Camillo Marra, Marcello D’Ascenzo, Claudio Grassi
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Stem Cell Research & Therapy
Subjects:
Nucleoporin
Neurogenesis
Alzheimer’s disease
Organoids
Online Access:https://doi.org/10.1186/s13287-024-03805-1
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https://doi.org/10.1186/s13287-024-03805-1

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