Antioxidants in neuropsychiatric disorder prevention: neuroprotection, synaptic regulation, microglia modulation, and neurotrophic effects
Oxidative stress, caused by an imbalance between the generation of reactive oxygen species (ROS) and the body’s intrinsic antioxidant defenses, plays a critical role in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. Beyond these conditions, recent evidence indicates t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1505153/full |
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| author | Fangfei Liu Qianqian Bai Wenchao Tang Shumin Zhang Yan Guo Shunji Pan Xiaoyu Ma Yanhui Yang Hua Fan |
| author_facet | Fangfei Liu Qianqian Bai Wenchao Tang Shumin Zhang Yan Guo Shunji Pan Xiaoyu Ma Yanhui Yang Hua Fan |
| author_sort | Fangfei Liu |
| collection | DOAJ |
| description | Oxidative stress, caused by an imbalance between the generation of reactive oxygen species (ROS) and the body’s intrinsic antioxidant defenses, plays a critical role in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. Beyond these conditions, recent evidence indicates that dysregulated redox balance is implicated in neuropsychiatric disorders, including schizophrenia, major depressive disorder, and anxiety disorders. Preclinical and clinical studies have demonstrated the potential of antioxidants, such as N-acetylcysteine, sulforaphane, alpha-lipoic acid, L-carnitine, ascorbic acid, selenocompounds, flavones and zinc, in alleviating neuropsychiatric symptoms by mitigating excitotoxicity, enhancing synaptic plasticity, reducing microglial overactivation and promoting synaptogenesis. This review explores the role of oxidative stress in the pathogenesis of neuropsychiatric disorders. It provides an overview of the current evidence on antioxidant therapy’s pharmacological effects, as demonstrated in animal models and clinical studies. It also discusses the underlying mechanisms and future directions for developing antioxidant-based adjuvant therapies. Given the limitations and side effects of existing treatments for neuropsychiatric disorders, antioxidant therapy presents a promising, safer alternative. Further research is essential to deepen our understanding and investigate the clinical efficacy and mechanisms underlying these therapies. |
| format | Article |
| id | doaj-art-48ea3c5ebe3e4501bf7e7fd6d693a750 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-48ea3c5ebe3e4501bf7e7fd6d693a7502024-12-05T06:28:57ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-12-011810.3389/fnins.2024.15051531505153Antioxidants in neuropsychiatric disorder prevention: neuroprotection, synaptic regulation, microglia modulation, and neurotrophic effectsFangfei Liu0Qianqian Bai1Wenchao Tang2Shumin Zhang3Yan Guo4Shunji Pan5Xiaoyu Ma6Yanhui Yang7Hua Fan8The First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaThe First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaThe First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaThe First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaThe First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaThe First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaThe First Affiliated Hospital, College of Clinical Medicine of Henan University of Science and Technology, Luoyang, ChinaDepartment of Trauma Center, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, ChinaOffice of Research and Innovation, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, ChinaOxidative stress, caused by an imbalance between the generation of reactive oxygen species (ROS) and the body’s intrinsic antioxidant defenses, plays a critical role in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s. Beyond these conditions, recent evidence indicates that dysregulated redox balance is implicated in neuropsychiatric disorders, including schizophrenia, major depressive disorder, and anxiety disorders. Preclinical and clinical studies have demonstrated the potential of antioxidants, such as N-acetylcysteine, sulforaphane, alpha-lipoic acid, L-carnitine, ascorbic acid, selenocompounds, flavones and zinc, in alleviating neuropsychiatric symptoms by mitigating excitotoxicity, enhancing synaptic plasticity, reducing microglial overactivation and promoting synaptogenesis. This review explores the role of oxidative stress in the pathogenesis of neuropsychiatric disorders. It provides an overview of the current evidence on antioxidant therapy’s pharmacological effects, as demonstrated in animal models and clinical studies. It also discusses the underlying mechanisms and future directions for developing antioxidant-based adjuvant therapies. Given the limitations and side effects of existing treatments for neuropsychiatric disorders, antioxidant therapy presents a promising, safer alternative. Further research is essential to deepen our understanding and investigate the clinical efficacy and mechanisms underlying these therapies.https://www.frontiersin.org/articles/10.3389/fnins.2024.1505153/fulloxidative stressneuropsychiatric disordersantioxidantsneuroprotectionsynaptic regulationmicroglia modulation |
| spellingShingle | Fangfei Liu Qianqian Bai Wenchao Tang Shumin Zhang Yan Guo Shunji Pan Xiaoyu Ma Yanhui Yang Hua Fan Antioxidants in neuropsychiatric disorder prevention: neuroprotection, synaptic regulation, microglia modulation, and neurotrophic effects Frontiers in Neuroscience oxidative stress neuropsychiatric disorders antioxidants neuroprotection synaptic regulation microglia modulation |
| title | Antioxidants in neuropsychiatric disorder prevention: neuroprotection, synaptic regulation, microglia modulation, and neurotrophic effects |
| title_full | Antioxidants in neuropsychiatric disorder prevention: neuroprotection, synaptic regulation, microglia modulation, and neurotrophic effects |
| title_fullStr | Antioxidants in neuropsychiatric disorder prevention: neuroprotection, synaptic regulation, microglia modulation, and neurotrophic effects |
| title_full_unstemmed | Antioxidants in neuropsychiatric disorder prevention: neuroprotection, synaptic regulation, microglia modulation, and neurotrophic effects |
| title_short | Antioxidants in neuropsychiatric disorder prevention: neuroprotection, synaptic regulation, microglia modulation, and neurotrophic effects |
| title_sort | antioxidants in neuropsychiatric disorder prevention neuroprotection synaptic regulation microglia modulation and neurotrophic effects |
| topic | oxidative stress neuropsychiatric disorders antioxidants neuroprotection synaptic regulation microglia modulation |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1505153/full |
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