A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback.

A novel TGFβ modulator that uncouples R-Smad/I-Smad-mediated negative feedback from R-Smad/ligand-driven positive feedback.

As some of the most widely utilised intercellular signalling molecules, transforming growth factor β (TGFβ) superfamily members play critical roles in normal development and become disrupted in human disease. Establishing appropriate levels of TGFβ signalling involves positive and negative feedback,...

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Main Authors: Wenchao Gu, Rui Monteiro, Jie Zuo, Filipa Costa Simões, Andrea Martella, Charlotte Andrieu-Soler, Frank Grosveld, Tatjana Sauka-Spengler, Roger Patient
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002051
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https://doi.org/10.1371/journal.pbio.1002051

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