Surfactant Protein A Inhibits Human Rhinovirus C Binding and Infection of Airway Epithelial Cells from Pediatric Asthma

Surfactant Protein A Inhibits Human Rhinovirus C Binding and Infection of Airway Epithelial Cells from Pediatric Asthma

Rhinovirus C (RV-C) infection can trigger asthma exacerbations in children and adults, and RV-C-induced wheezing illnesses in preschool children correlate with the development of childhood asthma. Surfactant protein A (SP-A) plays a critical role in regulating pulmonary innate immunity by binding to...

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Bibliographic Details
Main Authors: Sasipa Tanyaratsrisakul, Yury A. Bochkov, Vanessa White, Heejung Lee, Jessica Loeffler, Jamie Everman, Allison M. Schiltz, Kristy L. Freeman, Katharine L. Hamlington, Elizabeth A. Secor, Nathan D. Jackson, Hong Wei Chu, Andrew H. Liu, Julie G. Ledford, Monica Kraft, Max A. Seibold, Dennis R. Voelker, Mari Numata
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Viruses
Subjects:
pulmonary surfactant protein A
human rhinovirus C
pediatric asthma
innate immunity
Online Access:https://www.mdpi.com/1999-4915/16/11/1709
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