Uridine alleviates the aging of alveolar epithelial cells in idiopathic pulmonary fibrosis through the Keap1-Nrf2 signaling pathway

Uridine alleviates the aging of alveolar epithelial cells in idiopathic pulmonary fibrosis through the Keap1-Nrf2 signaling pathway

Abstract Idiopathic pulmonary fibrosis (IPF) is an age-related disease with an unclear pathogenesis. The senescence and insufficient regeneration of alveolar epithelial cells are significant factors in the development and progression of IPF. Currently, effective treatment methods are lacking. The ai...

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Bibliographic Details
Main Authors: Chenchun Ding, Renjie Zuo, Quan Liao, Zhenzhen Guo, Junjie He, Ziwei Ye, Guoyan Liu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Idiopathic pulmonary fibrosis (IPF)
Uridine; Senescence
Nrf2 signaling pathway
p62/SQSTM1
Online Access:https://doi.org/10.1038/s41598-025-04053-w
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https://doi.org/10.1038/s41598-025-04053-w

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