The Lachnospiraceae-butyric acid axis and its role in glucocorticoid-associated osteonecrosis

The Lachnospiraceae-butyric acid axis and its role in glucocorticoid-associated osteonecrosis

Abstract Glucocorticoids (GCs) are key inducers of osteonecrosis, yet not all patients treated with GCs develop glucocorticoid-associated osteonecrosis (GAON). The factors mediating this relationship are unclear. Studies have shown that gut microbiota and their metabolites influence bone metabolism,...

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Bibliographic Details
Main Authors: Mingbin Guo, Shuai He, Wei Song, Jianbin Mai, Xinwei Yuan, Yixuan Huang, Hongzhong Xi, Guangquan Sun, Yugen Chen, Bin Du, Xin Liu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Translational Medicine
Subjects:
Glucocorticoid associated osteonecrosis
Gut microbiota
Lachnospiraceae
Inflammatory immune response
Butyric acid
Mendelian randomization
Online Access:https://doi.org/10.1186/s12967-024-05813-4
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https://doi.org/10.1186/s12967-024-05813-4

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