Childhood lung function is associated with adolescent-onset and persistent asthma
Background Asthma is associated with impaired lung function; however, it is uncertain if a lower childhood lung function is associated with asthma onset and persistence during adolescence. The aims of the present study were to investigate the association between childhood lung function and onset and...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2024-12-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/10/6/00469-2024.full |
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| author | Hans Jacob L. Koefoed Anhar Ullah Jenny Hallberg Simon Kebede Merid Maura M. Kere Lesley Lowe Angela Simpson Clare S. Murray Ulrike Gehring Roel Vermeulen Inger Kull Anna Bergström Judith M. Vonk Adnan Custovic Erik Melén Gerard H. Koppelman |
| author_facet | Hans Jacob L. Koefoed Anhar Ullah Jenny Hallberg Simon Kebede Merid Maura M. Kere Lesley Lowe Angela Simpson Clare S. Murray Ulrike Gehring Roel Vermeulen Inger Kull Anna Bergström Judith M. Vonk Adnan Custovic Erik Melén Gerard H. Koppelman |
| author_sort | Hans Jacob L. Koefoed |
| collection | DOAJ |
| description | Background
Asthma is associated with impaired lung function; however, it is uncertain if a lower childhood lung function is associated with asthma onset and persistence during adolescence. The aims of the present study were to investigate the association between childhood lung function and onset and persistence of asthma during adolescence.
Methods
In the population-based BAMSE (Sweden), PIAMA (Netherlands) and MAAS (UK) birth cohorts, we analysed the association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC and forced expiratory volume at 75% of FVC at age 8 years with asthma onset and persistence in adolescence (age 12–16 years) using cohort-specific logistic regression analysis followed by meta-analysis.
Results
In the BAMSE, PIAMA and MAAS cohorts, asthma incidence in adolescence was 6.1% (112/1824), 3.4% (36/1050) and 5.0% (39/779), respectively. Persistent asthma from childhood to adolescence was observed in 8.2%, 6.4% and 7.7% of all subjects within the respective cohorts. A higher FEV1 % predicted and FEV1/FVC at age 8 years was associated with a lower odds for adolescent-onset asthma: OR 0.98 (95% CI 0.97–1.00) and 0.97 (0.94–0.99). These associations remained significant also when restricting the analyses to subjects with no wheezing or asthma treatment in childhood. A higher FEV1/FVC at age 8 years was associated with a lower odds for asthma persistence in adolescence (0.96 (0.93–0.99)). Sex by lung function interaction analysis was not significant.
Conclusions
A higher lung function at school age was associated with a lower risk of adolescent-onset asthma, predominantly in males. This indicates that a lower lung function in childhood may precede and or potentially contribute to asthma incidence and persistence. |
| format | Article |
| id | doaj-art-4732a08876ec4447bd8f129c6f83a135 |
| institution | Kabale University |
| issn | 2312-0541 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-4732a08876ec4447bd8f129c6f83a1352025-01-14T09:50:22ZengEuropean Respiratory SocietyERJ Open Research2312-05412024-12-0110610.1183/23120541.00469-202400469-2024Childhood lung function is associated with adolescent-onset and persistent asthmaHans Jacob L. Koefoed0Anhar Ullah1Jenny Hallberg2Simon Kebede Merid3Maura M. Kere4Lesley Lowe5Angela Simpson6Clare S. Murray7Ulrike Gehring8Roel Vermeulen9Inger Kull10Anna Bergström11Judith M. Vonk12Adnan Custovic13Erik Melén14Gerard H. Koppelman15 University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, the Netherlands National Heart and Lung Institute, Imperial College London, London, UK Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden Division of Immunology, Immunity to infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK Division of Immunology, Immunity to infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK Division of Immunology, Immunity to infection and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK Institute of Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands Institute of Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, the Netherlands National Heart and Lung Institute, Imperial College London, London, UK Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, Groningen, the Netherlands Background Asthma is associated with impaired lung function; however, it is uncertain if a lower childhood lung function is associated with asthma onset and persistence during adolescence. The aims of the present study were to investigate the association between childhood lung function and onset and persistence of asthma during adolescence. Methods In the population-based BAMSE (Sweden), PIAMA (Netherlands) and MAAS (UK) birth cohorts, we analysed the association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC and forced expiratory volume at 75% of FVC at age 8 years with asthma onset and persistence in adolescence (age 12–16 years) using cohort-specific logistic regression analysis followed by meta-analysis. Results In the BAMSE, PIAMA and MAAS cohorts, asthma incidence in adolescence was 6.1% (112/1824), 3.4% (36/1050) and 5.0% (39/779), respectively. Persistent asthma from childhood to adolescence was observed in 8.2%, 6.4% and 7.7% of all subjects within the respective cohorts. A higher FEV1 % predicted and FEV1/FVC at age 8 years was associated with a lower odds for adolescent-onset asthma: OR 0.98 (95% CI 0.97–1.00) and 0.97 (0.94–0.99). These associations remained significant also when restricting the analyses to subjects with no wheezing or asthma treatment in childhood. A higher FEV1/FVC at age 8 years was associated with a lower odds for asthma persistence in adolescence (0.96 (0.93–0.99)). Sex by lung function interaction analysis was not significant. Conclusions A higher lung function at school age was associated with a lower risk of adolescent-onset asthma, predominantly in males. This indicates that a lower lung function in childhood may precede and or potentially contribute to asthma incidence and persistence.http://openres.ersjournals.com/content/10/6/00469-2024.full |
| spellingShingle | Hans Jacob L. Koefoed Anhar Ullah Jenny Hallberg Simon Kebede Merid Maura M. Kere Lesley Lowe Angela Simpson Clare S. Murray Ulrike Gehring Roel Vermeulen Inger Kull Anna Bergström Judith M. Vonk Adnan Custovic Erik Melén Gerard H. Koppelman Childhood lung function is associated with adolescent-onset and persistent asthma ERJ Open Research |
| title | Childhood lung function is associated with adolescent-onset and persistent asthma |
| title_full | Childhood lung function is associated with adolescent-onset and persistent asthma |
| title_fullStr | Childhood lung function is associated with adolescent-onset and persistent asthma |
| title_full_unstemmed | Childhood lung function is associated with adolescent-onset and persistent asthma |
| title_short | Childhood lung function is associated with adolescent-onset and persistent asthma |
| title_sort | childhood lung function is associated with adolescent onset and persistent asthma |
| url | http://openres.ersjournals.com/content/10/6/00469-2024.full |
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