Development and evaluation of a recombinant monoclonal human antibody with virus-neutralizing activity against the F glycoprotein of respiratory syncytial virus

Development and evaluation of a recombinant monoclonal human antibody with virus-neutralizing activity against the F glycoprotein of respiratory syncytial virus

Introduction. Respiratory syncytial virus (RSV) is the most common pathogen causing lower respiratory tract infections in children. RSV also poses a serious threat to the elderly and immunocompromised patients. Developing a therapy based on recombinant human antibodies to block the RSV fusion (F) gl...

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Main Authors: Sergey A. Klotchenko, Ekaterina A. Romanovskaya-Romanko, Marina A. Plotnikova, Anastasia A. Pulkina, Aram A. Shaldzhyan, Dmitry S. Balabashin, Victoria A. Toporova, Teimur K. Aliev, Natalia E. Gyulikhandanova, Dmitry A. Lioznov
Format: Article
Language:Russian
Published: Central Research Institute for Epidemiology 2024-12-01
Series:Журнал микробиологии, эпидемиологии и иммунобиологии
Subjects:
therapeutic monoclonal antibodies
respiratory syncytial virus
fusion (f) glycoprotein
neutralization assay
cho cell line for recombinant antibodies production
vero cells
Online Access:https://microbiol.crie.ru/jour/article/viewFile/18697/1548
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