Unveiling tissue-specific transcriptional adaptations in iPSC-derived fibroblasts via co-culture systems

Unveiling tissue-specific transcriptional adaptations in iPSC-derived fibroblasts via co-culture systems

Abstract Background Induced pluripotent stem cell-derived fibroblasts (iFBs) hold promise for autologous disease modelling, but their ability to replicate tissue-specific fibroblast characteristics remains unclear. Fibroblasts exhibit significant heterogeneity, with distinct subtypes playing critica...

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Bibliographic Details
Main Authors: Amar J. Azad, Alessandro Bentivogli, Henrike Germar, Dana Wörz, Elena Lizunova, Max J. Cumberland, January Weiner, Sarah Hedtrich
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Stem Cell Research & Therapy
Subjects:
iPSCs
Fibroblast heterogeneity
iPSC-derived fibroblasts
Single-cell deconvolution
Fibroblast plasticity
Organ-specific fibroblasts
Online Access:https://doi.org/10.1186/s13287-025-04537-6
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