A proof-of-concept study of personalized dosimetry for targeted radioligand therapy using pre-treatment diagnostic dynamic PET/CT and Monte Carlo simulation

A proof-of-concept study of personalized dosimetry for targeted radioligand therapy using pre-treatment diagnostic dynamic PET/CT and Monte Carlo simulation

PurposeTheranostics integrates diagnostic imaging (e.g., 18F-PSMA-1007 PET) with targeted radioligand therapy (TRT; e.g., 177Lu-PSMA-617), but personalized dosimetry remains challenging due to complex dose calculations. Current methods like Monte Carlo simulations are accurate but require impractica...

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Bibliographic Details
Main Authors: Thanh Tai Duong, Danny De Sarno, Hatim Fakir, Glenn Bauman, Martin Martinov, Rowan M. Thomson, Ting-Yim Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
targeted radioligand therapy (TRT)
personalized dosimetry
Monte Carlo simulation
tracer kinetics
177Lu-PSMA-617
biological effective dose (BED)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1600821/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1600821/full

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