Dissolving microneedles enabled delivery of Oxaliplatin- sodium butyrate loaded outer membrane vesicles against rectal cancer

Dissolving microneedles enabled delivery of Oxaliplatin- sodium butyrate loaded outer membrane vesicles against rectal cancer

Abstract Background Oxaliplatin (OXA) is a commonly used drug for the treatment of rectal cancer (RC). However, traditional administration methods are plagued by low efficiency, high systemic side effects, and poor patient tolerance. Therefore, there is an urgent need to develop a targeted drug deli...

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Bibliographic Details
Main Authors: Chu Jian, Qu Zhanbo, Wu Yinhang, Xu Yating, Huang Bo, Wang Yingchen, Zhuang Jing, Wang Zefeng, Wu Zheng, Yu Xiang, Han Shuwen
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Rectal cancer
Oxaliplatin
Sodium butyrate
Outer membrane vesicles
Microneedles
Online Access:https://doi.org/10.1186/s12967-025-06921-5
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https://doi.org/10.1186/s12967-025-06921-5

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