Glucose-induced STUB1-GOT2 axis promotes aspartate synthesis and mitochondrial dysfunction in bladder cancer

Glucose-induced STUB1-GOT2 axis promotes aspartate synthesis and mitochondrial dysfunction in bladder cancer

Abstract Aberrant glucose metabolism, a characteristic of malignant tumors, contributes to the development and progression of bladder cancer (BCa). However, the underlying mechanism by which aberrant glucose metabolism promotes BCa progression is still incompletely understood. Here, we demonstrate t...

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Main Authors: Yunqiang Xiong, Qianxi Dong, Hongji Hu, Zhongqi Li, Xiangpeng Zhan, Fuchun Zheng, Hao Wan, Jiahao Liu, Shuyu Wu, Wang Pan, Ruize Yuan, Jing Xiong, Ju Guo, Songhui Xu, Bin Fu
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07840-5
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https://doi.org/10.1038/s41419-025-07840-5

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