Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression

Adipocyte-specific Zeb1 downregulation remodels the tumor-associated adipose microenvironment to facilitate female breast cancer progression

Abstract Upon penetrating the basement membrane, breast cancer cells directly interact with their surrounding adipose tissue, which forms a unique tumor-associated adipose microenvironment (TAME). However, the underlying mechanism of lipid metabolic remodeling in the TAME remains elusive. Herein, we...

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Main Authors: Lixia Cao, Wei Sun, Xiao Chen, Lei Liu, Shaorong Zhao, Jingjing Liu, Yang Ou, Min Guo, Chunchun Qi, Zhaoxian Li, Jie Shi, Yuxin Liu, Qiuying Shuai, Siyu Zuo, Huayu Hu, Tianwen Yu, Yanjing Wang, Mengdan Feng, Jianying Lv, Hang Wang, Peiqing Sun, Jin Zhang, Longlong Wang, Yi Shi, Shuang Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61088-3
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https://doi.org/10.1038/s41467-025-61088-3

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