Orange peel ethanolic extract and physical exercise prevent testicular toxicity in streptozocin and high fat diet-induced type 2 diabetes rats via Nrf2/NF-kB signaling: In silico and in vivo studies

Orange peel ethanolic extract and physical exercise prevent testicular toxicity in streptozocin and high fat diet-induced type 2 diabetes rats via Nrf2/NF-kB signaling: In silico and in vivo studies

Background: Type 2 diabetes mellitus (T2DM) is a significant health issue affecting the quality of life including male reproductive functions. Orange peel ethanolic extract (OPEE) has been established to have antioxidant properties and has been shown to alleviate diabetic complications. This study d...

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Main Authors: Adeyemi Fatai Odetayo, Ayodeji Johnson Ajibare, Kazeem Bidemi Okesina, Tunmise Marryane Akhigbe, Ezekiel Abiola Olugbogi, Luqman Aribidesi Olayaki
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Heliyon
Subjects:
Diabetes mellitus
Oxidative stress
Molecular docking
Apoptosis
Testicular dysfunction
Male fertility
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024158112
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