Intratumor morphologic and molecular genetic heterogeneity in astrocytomas of different grade of malignancy in the material from the first operation

Intratumor morphologic and molecular genetic heterogeneity in astrocytomas of different grade of malignancy in the material from the first operation

Introduction. Intratumor heterogeneity is one of the key reasons for unfavourable prognosis in malignant tumors. Astrocytic tumors are known to develop therapy resistance inevitably during the course of disease. One of possible reason is tumor heterogeneity. Purpose. The aim of this work was to asse...

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Bibliographic Details
Main Authors: D. E. Matsko, M. V. Matsko, A. O. Baksheeva, E. N. Imyanitov, A. Yu. Ulitin, V. M. Moiseenko, K. V. Shelekhova, N. M. Volkov, A. G. Ievleva, V. I. Tiurin, S. S. Sklyar, A. A. Zrelov, A. S. Morozova
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2022-01-01
Series:Сибирский онкологический журнал
Subjects:
glioblastoma
astrocytoma
intratumor heterogeneity
morphologic heterogeneity
moleculargenetic heterogeneity
gene expression
idh1 and idh2 mutations
Online Access:https://www.siboncoj.ru/jour/article/view/1985
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