Conserved multiepitopes in Plasmodium falciparum STEVORs enable rational design of a fusion antigen vaccine construct with broad immunogenicity

Conserved multiepitopes in Plasmodium falciparum STEVORs enable rational design of a fusion antigen vaccine construct with broad immunogenicity

There is no vaccine for severe malaria. STEVOR antigens on the surface of Plasmodium falciparum-infected red blood cells are implicated in severe malaria and are targeted by neutralizing antibodies, but their epitopes remain unknown. Using computational immunology, we identified highly immunogenic o...

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Main Authors: Zhi-Shan Sun, Jing-Xian Yin, Han-Qing Zhao, Yin-shan Zhu, Shen-Bo Chen, Hai-Mo Shen, Bin Xu, Xiao-Nong Zhou, Tian-Yu Wang, Wan-Xuan Yang, Yi-Wen Duan, Jun-Hu Chen, Kokouvi Kassegne
Format: Article
Language:English
Published: Taylor & Francis Group 2025-08-01
Series:Emerging Microbes and Infections
Subjects:
Plasmodium falciparum
severe malaria
STEVOR
multiepitope
immunogenicity
vaccine construct
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2552783
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https://www.tandfonline.com/doi/10.1080/22221751.2025.2552783

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