Kolmogorov–Arnold Network Model Integrated with Hypoxia Risk for Predicting PD-L1 Inhibitor Responses in Hepatocellular Carcinoma

Kolmogorov–Arnold Network Model Integrated with Hypoxia Risk for Predicting PD-L1 Inhibitor Responses in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, with immunotherapy being a first-line treatment at the advanced stage and beyond. Hypoxia plays a critical role in tumor progression and resistance to therapy. This study develops and validates an artificial intelligence (AI...

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Bibliographic Details
Main Authors: Mohan Huang, Xinyue Chen, Yi Jiang, Lawrence Wing Chi Chan
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Bioengineering
Subjects:
hepatocellular carcinoma
hypoxia
immunotherapy response
Kolmogorov–Arnold network
support vector machine
Online Access:https://www.mdpi.com/2306-5354/12/3/322
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