SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer

SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer

Abstract Despite progress significant advances in immunotherapy for some solid tumors, pancreatic ductal adenocarcinoma (PDAC) remains unresponsive poorly responsive to such interventions, largely due to its highly immunosuppressive tumor microenvironment (TME) with limited CD8+ T cell infiltration....

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Bibliographic Details
Main Authors: Zhengyan Zhang, Yingying Tang, Yu Wang, Junyi Xu, Xiaotong Yang, Mingzhu Liu, Massimiliano Mazzone, Ningning Niu, Yongwei Sun, Yujie Tang, Jing Xue
Format: Article
Language:English
Published: Wiley 2024-11-01
Series:Advanced Science
Subjects:
anti‐PD1 treatment
CD8+ T cell infiltration
CXCL9/10‐CXCR3 axis
pancreatic ductal adenocarcinoma
tumor microenvironment
Sin3B
Online Access:https://doi.org/10.1002/advs.202402244
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https://doi.org/10.1002/advs.202402244

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