Heterogeneity in polyamine metabolism dictates prognosis and immune checkpoint blockade response in hepatocellular carcinoma

Heterogeneity in polyamine metabolism dictates prognosis and immune checkpoint blockade response in hepatocellular carcinoma

Immune checkpoint blockade holds promise in hepatocellular carcinoma (HCC) treatment, but its efficacy remains limited. Dysregulated polyamine metabolism and its interaction with oncogenic pathways promote tumor progression. However, the heterogeneity of polyamine metabolism and its effects on the i...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jianyan Pan, Zhong Lin, Qinchun Pan, Tao Zhu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-02-01
Series:	Frontiers in Immunology
Subjects:	hepatocellular carcinoma polyamine metabolic heterogeneity immunotherapy prognosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1516332/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Spatial heterogeneity of the hepatocellular carcinoma microenvironment determines the efficacy of immunotherapy
by: Minni Zhang, et al.
Published: (2025-01-01)

Cryoablation combined with dual immune checkpoint blockade enhances antitumor efficacy in hepatocellular carcinoma model mice
by: Jun Gu, et al.
Published: (2024-12-01)

Magnetic resonance imaging radiomics based on artificial intelligence is helpful to evaluate the prognosis of single hepatocellular carcinoma
by: Jing Zhou, et al.
Published: (2025-01-01)

Reversing NK cell exhaustion: a novel strategy combining immune checkpoint blockade with drug sensitivity enhancement in the treatment of hepatocellular carcinoma
by: Yuxiang Huang, et al.
Published: (2025-01-01)

Exploring prognosis and therapeutic strategies for HBV-HCC patients based on disulfidptosis-related genes
by: Chuankuo Zhang, et al.
Published: (2025-01-01)

Polyamine Content of Enteral Nutrition Formulas: Effect of Daily Intake on the Feeding Tolerance of Patients During the First Week in the Intensive Care Unit
by: Manuel Sánchez, et al.
Published: (2025-01-01)

Single-cell mitophagy patterns within the tumor microenvironment modulate intercellular communication, impacting the progression and prognosis of hepatocellular carcinoma
by: Zhengyan Li, et al.
Published: (2025-01-01)

Prognostic impact of presenting symptoms of patients with hepatocellular carcinoma
by: Samuel Jun Ming Lim, et al.
Published: (2024-08-01)

TMEM101 expression and its impact on immune cell infiltration and prognosis in hepatocellular carcinoma
by: Lingyun Kuang, et al.
Published: (2024-12-01)

To construct and validate a risk score model of angiogenesis-related genes to predict the prognosis of hepatocellular carcinoma
by: Duangui Gao, et al.
Published: (2025-02-01)

Effect of biogenic polyamines on sliding motility of mycobacteria in the presence of antibiotics
by: I. V. Tsyganov, et al.
Published: (2022-09-01)

Antiviral therapy can effectively suppress irAEs in HBV positive hepatocellular carcinoma treated with ICIs: validation based on multi machine learning
by: Shuxian Pan, et al.
Published: (2025-01-01)

Effects of polyamines and indole on the expression of ribosome hibernation factors in <i>Escherichia coli</i> at the translational level
by: E. A. Khaova, et al.
Published: (2024-03-01)

Structural insights into antibody-based immunotherapy for hepatocellular carcinoma
by: Masaud Shah, et al.
Published: (2025-01-01)

Salivary microbiota dysbiosis and elevated polyamine levels contribute to the severity of periodontal disease
by: Md Haroon Rashid, et al.
Published: (2025-01-01)

CK19 protein expression: the best cutoff value on the prognosis and the prognosis model of hepatocellular carcinoma
by: Chenglei Yang, et al.
Published: (2025-01-01)

The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome
by: Filiz Yarsilikal Guleroglu, et al.
Published: (2025-01-01)

Radiofrequency ablation combined with immunotherapy to treat hepatocellular carcinoma: a comprehensive review
by: Gui-Lin Xie, et al.
Published: (2025-01-01)

Utilizing liquid-liquid biopolymer regulators to predict the prognosis and drug sensitivity of hepatocellular carcinoma
by: Jianhao Li, et al.
Published: (2025-01-01)

Assessment of Tumor Burden Score as a Feasible and Reliable Tool for Prognosis Prediction for Hepatocellular Carcinoma Undergoing Hepatectomy: A Multicenter, Retrospective Study
by: Guan R, et al.
Published: (2025-02-01)

A novel mitochondrial-related risk model for predicting prognosis and immune checkpoint blockade therapy response in uterine corpus endometrial carcinoma
by: Ru-Gen Liao, et al.
Published: (2025-01-01)

Identification of a novel immunogenic cell death-related classifier to predict prognosis and optimize precision treatment in hepatocellular carcinoma
by: Dongjing Zhang, et al.
Published: (2025-01-01)

Harnessing nanoparticles for reshaping tumor immune microenvironment of hepatocellular carcinoma
by: JinSong Li, et al.
Published: (2025-02-01)

Single-cell landscape of dynamic changes in CD8+ T cells, CD4+ T cells and exhausted T cells in hepatocellular carcinoma
by: Rongqiang Liu, et al.
Published: (2025-02-01)

Serum proteomic and metabolomic profiling of hepatocellular carcinoma patients co-infected with Clonorchis sinensis
by: Zeli Tang, et al.
Published: (2025-01-01)

FLT3 is associated with dendritic cell infiltration, tertiary lymphoid structure construction, and predict response to checkpoint inhibitors immunotherapy in solid cancers
by: Yongchang Tang, et al.
Published: (2025-01-01)

RETRACTED ARTICLE: Single-cell omics and machine learning integration to develop a polyamine metabolism-based risk score model in breast cancer patients
by: Xiliang Zhang, et al.
Published: (2024-10-01)

Prognostic Value of N1/N2 Neutrophils Heterogeneity and Tertiary Lymphoid Structure in Hepatocellular Carcinoma Patients
by: Yanfei Lang, et al.
Published: (2024-12-01)

Preoperative serum glutathione reductase activity and alpha-fetoprotein level are associated with early postoperative recurrence of hepatocellular carcinoma
by: Shen Lihong, et al.
Published: (2025-02-01)

A New Risk Score Based on Lipid Indicators for Patients with Advanced Hepatocellular Carcinoma
by: Wei X, et al.
Published: (2025-01-01)

Exploration of ANKRD27 as an immune-related prognostic factor in pan-cancer and hepatocellular carcinoma
by: Ningzhe Shen, et al.
Published: (2025-01-01)

Prognostic and diagnostic significance of circRNAs expression in hepatocellular carcinoma patients: A meta‐analysis
by: Xin Huang, et al.
Published: (2019-03-01)

Neoadjuvant atezolizumab plus bevacizumab prior liver transplantation for hepatocellular carcinoma
by: Parissa Tabrizian, et al.
Published: (2025-02-01)

The Clinical Characteristics, Patterns of Recurrence, and Long-Term Survival Outcomes of Dual-Phenotype Hepatocellular Carcinoma After Curative Liver Resection
by: Yu ZC, et al.
Published: (2025-01-01)

Evaluation of Treatment Outcomes Using dNLR and GNRI in Combination Therapy With Atezolizumab and Bevacizumab for Hepatocellular Carcinoma
by: Atsushi Naganuma, et al.
Published: (2025-01-01)

ALKBH5 acts a tumor-suppressive biomarker and is associated with immunotherapy response in hepatocellular carcinoma
by: Hehua Ma, et al.
Published: (2025-01-01)

Comprehensive analysis of publications concerning combinations of immunotherapy and targeted therapies for hepatocellular carcinoma: a bibliometric study
by: Biling Gan, et al.
Published: (2025-02-01)

Immune Checkpoint Blockade in Melanoma – Earlier is Better?
by: Vincas Urbonas, et al.
Published: (2024-09-01)

Integrating single-cell RNA-Seq and bulk RNA-Seq data to explore the key role of fatty acid metabolism in hepatocellular carcinoma
by: Hua Dai, et al.
Published: (2025-01-01)

Habitat radiomics based on CT images to predict survival and immune status in hepatocellular carcinoma, a multi-cohort validation study
by: Kun Chen, et al.
Published: (2025-02-01)