Case report: Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodies
We report a case of optic neuritis (ON) secondary to autoimmune encephalitis (AE) in a patient with concomitant antibodies to N-methyl-D-aspartate receptor (NMDAR), gamma-aminobutyric acid-B receptor (GABABR), and myelin oligodendrocyte glycoprotein (MOG). The patient exhibited a constellation of sy...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1461024/full |
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| author | Zhujun Mei Zhujun Mei Zhujun Mei Zhujun Mei Jingguo Wang Jingguo Wang Junling Wang Xiaoni Liu Xiaoni Liu Bo Deng Bo Deng Wenbo Yang Wenbo Yang Xiang Zhang Xiang Zhang Xiangjun Chen Xiangjun Chen Hai Yu Hai Yu |
| author_facet | Zhujun Mei Zhujun Mei Zhujun Mei Zhujun Mei Jingguo Wang Jingguo Wang Junling Wang Xiaoni Liu Xiaoni Liu Bo Deng Bo Deng Wenbo Yang Wenbo Yang Xiang Zhang Xiang Zhang Xiangjun Chen Xiangjun Chen Hai Yu Hai Yu |
| author_sort | Zhujun Mei |
| collection | DOAJ |
| description | We report a case of optic neuritis (ON) secondary to autoimmune encephalitis (AE) in a patient with concomitant antibodies to N-methyl-D-aspartate receptor (NMDAR), gamma-aminobutyric acid-B receptor (GABABR), and myelin oligodendrocyte glycoprotein (MOG). The patient exhibited a constellation of symptoms, including vision loss, seizures, mental and behavioral disorders, cognitive impairment, and speech abnormalities. At the two-year follow-up, the patient’s symptoms had abated entirely. Overlap syndrome of triple autoimmune antibodies is rare and the coexistence of antibodies to NMDAR, GABABR and MOG has not been reported till now. This case report provides novel experience of diagnosis and treatment in autoimmune overlap syndromes. |
| format | Article |
| id | doaj-art-42d0ad0a65cd4c639fab1a915979376f |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-42d0ad0a65cd4c639fab1a915979376f2025-01-14T05:10:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.14610241461024Case report: Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodiesZhujun Mei0Zhujun Mei1Zhujun Mei2Zhujun Mei3Jingguo Wang4Jingguo Wang5Junling Wang6Xiaoni Liu7Xiaoni Liu8Bo Deng9Bo Deng10Wenbo Yang11Wenbo Yang12Xiang Zhang13Xiang Zhang14Xiangjun Chen15Xiangjun Chen16Hai Yu17Hai Yu18Department of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, ChinaDepartment of Neurology, National Center for Neurological Disorders, Shanghai, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi (National Regional Center for Neurological Diseases), Nanchang, Jiangxi, ChinaJiangxi Provincial People’s Hospital, Clinical College of Nanchang Medical College, First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, ChinaDepartment of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, ChinaDepartment of Neurology, National Center for Neurological Disorders, Shanghai, ChinaDepartment of Neurology, Xiangya Hospital, Central South University, Jiangxi (National Regional Center for Neurological Diseases), Nanchang, Jiangxi, ChinaDepartment of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, ChinaDepartment of Neurology, National Center for Neurological Disorders, Shanghai, ChinaDepartment of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, ChinaDepartment of Neurology, National Center for Neurological Disorders, Shanghai, ChinaDepartment of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, ChinaDepartment of Neurology, National Center for Neurological Disorders, Shanghai, ChinaDepartment of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, ChinaDepartment of Neurology, National Center for Neurological Disorders, Shanghai, ChinaDepartment of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, ChinaDepartment of Neurology, National Center for Neurological Disorders, Shanghai, ChinaDepartment of Neurology, Huashan Hospital, Fudan University and Institute of Neurology, Fudan University, Shanghai, ChinaDepartment of Neurology, National Center for Neurological Disorders, Shanghai, ChinaWe report a case of optic neuritis (ON) secondary to autoimmune encephalitis (AE) in a patient with concomitant antibodies to N-methyl-D-aspartate receptor (NMDAR), gamma-aminobutyric acid-B receptor (GABABR), and myelin oligodendrocyte glycoprotein (MOG). The patient exhibited a constellation of symptoms, including vision loss, seizures, mental and behavioral disorders, cognitive impairment, and speech abnormalities. At the two-year follow-up, the patient’s symptoms had abated entirely. Overlap syndrome of triple autoimmune antibodies is rare and the coexistence of antibodies to NMDAR, GABABR and MOG has not been reported till now. This case report provides novel experience of diagnosis and treatment in autoimmune overlap syndromes.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1461024/fulloverlapping syndromeautoimmune encephalitis (AE)N-methyl-D-aspartate receptor (NMDAR)myelin oligodendrocyte glycoprotein (MOG)gamma-aminobutyric acid-B receptor (GABABR)optic neuritis (ON) |
| spellingShingle | Zhujun Mei Zhujun Mei Zhujun Mei Zhujun Mei Jingguo Wang Jingguo Wang Junling Wang Xiaoni Liu Xiaoni Liu Bo Deng Bo Deng Wenbo Yang Wenbo Yang Xiang Zhang Xiang Zhang Xiangjun Chen Xiangjun Chen Hai Yu Hai Yu Case report: Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodies Frontiers in Immunology overlapping syndrome autoimmune encephalitis (AE) N-methyl-D-aspartate receptor (NMDAR) myelin oligodendrocyte glycoprotein (MOG) gamma-aminobutyric acid-B receptor (GABABR) optic neuritis (ON) |
| title | Case report: Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodies |
| title_full | Case report: Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodies |
| title_fullStr | Case report: Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodies |
| title_full_unstemmed | Case report: Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodies |
| title_short | Case report: Overlapping syndrome of MOG-IgG associated optic neuritis and autoimmune encephalitis with co-existence of anti-NMDAR and anti-GABABR antibodies |
| title_sort | case report overlapping syndrome of mog igg associated optic neuritis and autoimmune encephalitis with co existence of anti nmdar and anti gababr antibodies |
| topic | overlapping syndrome autoimmune encephalitis (AE) N-methyl-D-aspartate receptor (NMDAR) myelin oligodendrocyte glycoprotein (MOG) gamma-aminobutyric acid-B receptor (GABABR) optic neuritis (ON) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1461024/full |
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