Hybrid Cannabis sativa L. inflorescences exert an anti-inflammatory effect through the modulation of MAPK/NF-κB/NLRP3 inflammasome and JAK1/STAT6 pathway in HaCaT cells

Hybrid Cannabis sativa L. inflorescences exert an anti-inflammatory effect through the modulation of MAPK/NF-κB/NLRP3 inflammasome and JAK1/STAT6 pathway in HaCaT cells

BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disease accompanied by severe itching. Reducing mediators of skin inflammation and itching is crucial for the treatment of AD. Cannabis sativa L. contains many types of cannabinoids and flavonoids, which exhibit antioxidant and anti-inf...

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Bibliographic Details
Main Authors: Ji-Ye Han, Do-Won Lim, Osoung Kwon, Yun Jung Lee, Hye Yung Choi, Hyun-Ju Jung, Soohyang Noh, Mansoo Cho, Sung Suk Kang, Young-Mi Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
Cannabis sativa L.
atopic dermatitis
inflammation
inflammatory diseases
skin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1617180/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1617180/full

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