Codon-deoptimized single-round infectious virus for therapeutic and vaccine applications

Abstract Coxsackievirus B3 (CVB3) is a major cause of myocarditis and acute pancreatitis, particularly in neonates, in whom infections result in severe symptoms and high mortality rates. Despite the urgent need for effective preventive strategies, no vaccines or therapeutic agents have been develope...

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Bibliographic Details
Main Authors: Takafumi Noguchi, Anju Miyamori, Takeshi Sugimoto, Paola Miyazato, Hirotaka Ebina
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-025-05643-4
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