Evasion of Apoptosis as a Cellular Stress Response in Cancer
One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis. Evasion of apoptosis can be part of a cellular stress response to ensure the cell's survival upon exposure to stressful stimuli. Apoptosis resistance may contribute to carcinogenesis, tumor progression,...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2010/370835 |
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| _version_ | 1841524715589468160 |
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| author | Simone Fulda |
| author_facet | Simone Fulda |
| author_sort | Simone Fulda |
| collection | DOAJ |
| description | One of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis. Evasion of apoptosis can be part of a cellular stress response to ensure the cell's survival upon exposure to stressful stimuli. Apoptosis resistance may contribute to carcinogenesis, tumor progression, and also treatment resistance, since most current anticancer therapies including chemotherapy as well as radio- and immunotherapies primarily act by activating cell death pathways including apoptosis in cancer cells. Hence, a better understanding of the molecular mechanisms regarding how cellular stress stimuli trigger antiapoptotic mechanisms and how this contributes to tumor resistance to apoptotic cell death is expected to provide the basis for a rational approach to overcome apoptosis resistance mechanisms in cancers. |
| format | Article |
| id | doaj-art-425aca63de274f74936c005d385ea518 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-425aca63de274f74936c005d385ea5182025-02-03T05:47:33ZengWileyInternational Journal of Cell Biology1687-88761687-88842010-01-01201010.1155/2010/370835370835Evasion of Apoptosis as a Cellular Stress Response in CancerSimone Fulda0Ulm University, Children's Hospital, Eythstraße 24, 89075 Ulm, GermanyOne of the hallmarks of human cancers is the intrinsic or acquired resistance to apoptosis. Evasion of apoptosis can be part of a cellular stress response to ensure the cell's survival upon exposure to stressful stimuli. Apoptosis resistance may contribute to carcinogenesis, tumor progression, and also treatment resistance, since most current anticancer therapies including chemotherapy as well as radio- and immunotherapies primarily act by activating cell death pathways including apoptosis in cancer cells. Hence, a better understanding of the molecular mechanisms regarding how cellular stress stimuli trigger antiapoptotic mechanisms and how this contributes to tumor resistance to apoptotic cell death is expected to provide the basis for a rational approach to overcome apoptosis resistance mechanisms in cancers.http://dx.doi.org/10.1155/2010/370835 |
| spellingShingle | Simone Fulda Evasion of Apoptosis as a Cellular Stress Response in Cancer International Journal of Cell Biology |
| title | Evasion of Apoptosis as a Cellular Stress Response in Cancer |
| title_full | Evasion of Apoptosis as a Cellular Stress Response in Cancer |
| title_fullStr | Evasion of Apoptosis as a Cellular Stress Response in Cancer |
| title_full_unstemmed | Evasion of Apoptosis as a Cellular Stress Response in Cancer |
| title_short | Evasion of Apoptosis as a Cellular Stress Response in Cancer |
| title_sort | evasion of apoptosis as a cellular stress response in cancer |
| url | http://dx.doi.org/10.1155/2010/370835 |
| work_keys_str_mv | AT simonefulda evasionofapoptosisasacellularstressresponseincancer |