A Black Sticky Rice-Derived Functional Ingredient Improves Anxiety, Depression, and Stress Perception in Adult Volunteers
We hypothesized that consumption of a diet containing the functional ingredient from black sticky rice, which is rich in anthocyanin, over a five-day period would improve anxiety, depression, and stress perception in adult volunteers based on the benefits of this compound. In this study, a total of...
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MDPI AG
2024-12-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/13/23/3884 |
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| author | Pattamaporn Natthee Jintanaporn Wattanathorn Wipawee Thukham-mee Pongsatorn Paholpak Poonsri Rangseekajee Nawanant Piyavhatkul Suphayanakorn Wattanathorn Supaporn Muchimapura Terdthai Tong-Un |
| author_facet | Pattamaporn Natthee Jintanaporn Wattanathorn Wipawee Thukham-mee Pongsatorn Paholpak Poonsri Rangseekajee Nawanant Piyavhatkul Suphayanakorn Wattanathorn Supaporn Muchimapura Terdthai Tong-Un |
| author_sort | Pattamaporn Natthee |
| collection | DOAJ |
| description | We hypothesized that consumption of a diet containing the functional ingredient from black sticky rice, which is rich in anthocyanin, over a five-day period would improve anxiety, depression, and stress perception in adult volunteers based on the benefits of this compound. In this study, a total of 46 male and female adult volunteers with mild and moderate stress level were assigned to groups consuming a breakfast meal containing an anthocyanin-enriched functional ingredient at doses of 2 and 4 g per day for 5 days. The volunteers consumed three meals with a low DII but high DAQ-S, and the total calories consumed during the study period was 2000 kcal/day. Mental well-being, including depression, anxiety, and stress, together with AChE, MAO, Nrf2, 8OHdG, MDA, and the density of <i>Lactobacillus</i> and <i>Bifidobacterium</i> spp., were assessed at baseline and at the end of the study. Safety parameters were also examined. A diet containing both doses of the anthocyanin-enriched functional ingredient with a low DII but high DAQ-S was found to improve anxiety, depression, and stress, with changes in 8-OHdG and IL-6 levels. No other changes and toxicity-related parameters were observed. Our results show that the novel functional ingredient can improve anxiety, depression, and stress perception partly by decreasing oxidative stress and inflammation; however, randomized, double-blind, placebo-controlled studies with a larger sample size should be performed to confirm this benefit. |
| format | Article |
| id | doaj-art-41fdd3dd88144c1ab22a1672d0c382d0 |
| institution | Kabale University |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-41fdd3dd88144c1ab22a1672d0c382d02024-12-13T16:26:54ZengMDPI AGFoods2304-81582024-12-011323388410.3390/foods13233884A Black Sticky Rice-Derived Functional Ingredient Improves Anxiety, Depression, and Stress Perception in Adult VolunteersPattamaporn Natthee0Jintanaporn Wattanathorn1Wipawee Thukham-mee2Pongsatorn Paholpak3Poonsri Rangseekajee4Nawanant Piyavhatkul5Suphayanakorn Wattanathorn6Supaporn Muchimapura7Terdthai Tong-Un8Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandResearch Institute for High Human Performance and Health Promotion, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, ThailandWe hypothesized that consumption of a diet containing the functional ingredient from black sticky rice, which is rich in anthocyanin, over a five-day period would improve anxiety, depression, and stress perception in adult volunteers based on the benefits of this compound. In this study, a total of 46 male and female adult volunteers with mild and moderate stress level were assigned to groups consuming a breakfast meal containing an anthocyanin-enriched functional ingredient at doses of 2 and 4 g per day for 5 days. The volunteers consumed three meals with a low DII but high DAQ-S, and the total calories consumed during the study period was 2000 kcal/day. Mental well-being, including depression, anxiety, and stress, together with AChE, MAO, Nrf2, 8OHdG, MDA, and the density of <i>Lactobacillus</i> and <i>Bifidobacterium</i> spp., were assessed at baseline and at the end of the study. Safety parameters were also examined. A diet containing both doses of the anthocyanin-enriched functional ingredient with a low DII but high DAQ-S was found to improve anxiety, depression, and stress, with changes in 8-OHdG and IL-6 levels. No other changes and toxicity-related parameters were observed. Our results show that the novel functional ingredient can improve anxiety, depression, and stress perception partly by decreasing oxidative stress and inflammation; however, randomized, double-blind, placebo-controlled studies with a larger sample size should be performed to confirm this benefit.https://www.mdpi.com/2304-8158/13/23/3884black sticky riceanthocyanindietary inflammatory indexantioxidant quality scoreanxietydepression |
| spellingShingle | Pattamaporn Natthee Jintanaporn Wattanathorn Wipawee Thukham-mee Pongsatorn Paholpak Poonsri Rangseekajee Nawanant Piyavhatkul Suphayanakorn Wattanathorn Supaporn Muchimapura Terdthai Tong-Un A Black Sticky Rice-Derived Functional Ingredient Improves Anxiety, Depression, and Stress Perception in Adult Volunteers Foods black sticky rice anthocyanin dietary inflammatory index antioxidant quality score anxiety depression |
| title | A Black Sticky Rice-Derived Functional Ingredient Improves Anxiety, Depression, and Stress Perception in Adult Volunteers |
| title_full | A Black Sticky Rice-Derived Functional Ingredient Improves Anxiety, Depression, and Stress Perception in Adult Volunteers |
| title_fullStr | A Black Sticky Rice-Derived Functional Ingredient Improves Anxiety, Depression, and Stress Perception in Adult Volunteers |
| title_full_unstemmed | A Black Sticky Rice-Derived Functional Ingredient Improves Anxiety, Depression, and Stress Perception in Adult Volunteers |
| title_short | A Black Sticky Rice-Derived Functional Ingredient Improves Anxiety, Depression, and Stress Perception in Adult Volunteers |
| title_sort | black sticky rice derived functional ingredient improves anxiety depression and stress perception in adult volunteers |
| topic | black sticky rice anthocyanin dietary inflammatory index antioxidant quality score anxiety depression |
| url | https://www.mdpi.com/2304-8158/13/23/3884 |
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