Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform ‘cold’ tumors into ‘hot’ tumors

Nanomedicines harnessing cGAS-STING pathway: sparking immune revitalization to transform ‘cold’ tumors into ‘hot’ tumors

Abstract cGAS-STING pathway stands at the forefront of innate immunity and plays a critical role in regulating adaptive immune responses, making it as a key orchestrator of anti-tumor immunity. Despite the great potential, clinical outcomes with cGAS-STING activators have been disappointing due to t...

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Bibliographic Details
Main Authors: Xiaohong Ying, Qiaohui Chen, Yongqi Yang, Ziyu Wu, Wan Zeng, Chenxi Miao, Qiong Huang, Kelong Ai
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Cancer
Subjects:
cGAS-STING pathway
Cancer immunotherapy
Nanomedicines
ExDNA
Chemotherapy
RT
Online Access:https://doi.org/10.1186/s12943-024-02186-6
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https://doi.org/10.1186/s12943-024-02186-6

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