FCGR3A F158V alleles frequency differs in multiple myeloma patients from healthy population

FCGR3A F158V alleles frequency differs in multiple myeloma patients from healthy population

FCGR3A presents a single nucleotide polymorphism at location 158 (V/F), which affects its binding to the fragment crystallizable (Fc) of antibodies (Abs). FcγRIIIa-158 V allotype has the highest affinity and is associated with a better clinical response to IgG1 monoclonal Abs (mAb) treatment. We com...

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Bibliographic Details
Main Authors: Michaël Constantinides, Nicolas Robert, Caroline Multrier, Loïs Coënon, Mauricio Campos-Mora, Carine Jacquard, Fei Gao, Sara Zemiti, Jessy Presumey, Guillaume Cartron, Jérome Moreaux, Martin Villalba
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
FCGR3A polymorphism
FcγRIIIa/CD16a
monoclonal gammopathy of undetermined significance (MGUS)
multiple myeloma (MM)
tumor environment
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2388306
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https://www.tandfonline.com/doi/10.1080/2162402X.2024.2388306

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