The bacterial type three secretion system induces mechanoporation of vacuolar membranes.

Endomembrane breaching is a crucial strategy employed by intracellular pathogens enclosed within vacuoles to access the nutrient-rich cytosol for intracellular replication. While bacteria use various mechanisms to compromise host membranes, the specific processes and factors involved are often unkno...

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Main Authors: Léa Swistak, Marvin Albert, Camila Valenzuela, Elif Begum Gokerkucuk, François Bontems, Stéphane Tachon, Keith T Egger, Anastasia D Gazi, Anna Sartori-Rupp, Cammie F Lesser, Perrine Paul-Gilloteaux, Jean-Yves Tinevez, Matthijn Vos, Jost Enninga
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3003135
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