Cranial radiation disrupts dopaminergic signaling and connectivity in the mammalian brain

Abstract Cognitive impairment is a common and challenging side effect of cranial radiation therapy for brain tumors, though its precise mechanisms remain unclear. The mesocortical dopaminergic pathway, known to play a key role in cognitive function, is implicated in several neuropsychiatric disorder...

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Bibliographic Details
Main Authors: Die Zhang, Riya Thomas, Thanh Thai Lam, Ines Veselinovic, David R. Grosshans
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Acta Neuropathologica Communications
Subjects:
Online Access:https://doi.org/10.1186/s40478-025-01976-3
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