Exosomes secreted by ATF3/Nrf2-mediated ferroptotic renal tubular epithelial cells promote M1/M2 ratio imbalance inducing renal interstitial fibrosis following ischemia and reperfusion injury

Exosomes secreted by ATF3/Nrf2-mediated ferroptotic renal tubular epithelial cells promote M1/M2 ratio imbalance inducing renal interstitial fibrosis following ischemia and reperfusion injury

BackgroundSevere renal ischemia and reperfusion injury (IRI) progresses to renal interstitial fibrosis (RIF) with limited therapeutic strategies. Although ferrptosis and macrophage polarization both play important roles in this model, their specific pathogenesis and interactions have not been elucid...

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Bibliographic Details
Main Authors: Qiao Tang, Jiatao Xie, Yifei Wang, Chong Dong, Qian Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
ischemia and reperfusion
renal interstitial fibrosis
ferroptosis
activation transcription factor 3
exosome
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1510500/full
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