Prognostic role of high MTAP expression is reversed by the ERG status in prostate cancer treated by radical prostatectomy

Prognostic role of high MTAP expression is reversed by the ERG status in prostate cancer treated by radical prostatectomy

Loss of S-methyl-5′-thioadenosine phosphorylase (MTAP) expression offers a therapeutic option through synthetic lethality and confers resistance to immune checkpoint inhibitors in various cancers. To assess MTAP prevalence in prostate cancer, a tissue microarray of 17,747 samples was analyzed via im...

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Main Authors: Natalia Gorbokon, Seyma Büyücek, Henning Plage, Neele Heckmann, Ronald Simon, Maximilian Lennartz, Martina Kluth, Katharina Teljuk, Claudia Hube-Magg, Sarah Minner, Eike Burandt, Till S. Clauditz, Waldemar Wilczak, Guido Sauter, David Dum, Andrea Hinsch, Hans Heinzer, Alexander Haese, Thorsten Schlomm, Andreas M Luebke, Markus Graefen, Stefan Steurer, Christian Bernreuther, Luca Roma, Lukas Bubendorf, Sarah Weinberger
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
MTAP
Prostate cancer
Tissue microarray
Prognosis
TMPRSS2:ERG fusion
Immunohistochemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000776
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