Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs

Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs

Summary: The tRNA methyltransferase 1 (TRMT1) enzyme catalyzes the N2,N2-dimethylguanosine (m2,2G) modification in tRNAs. Intriguingly, vertebrates encode an additional tRNA methyltransferase 1-like (TRMT1L) paralog. Here, we use a comprehensive tRNA sequencing approach to decipher targets of human...

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Main Authors: Kejia Zhang, Aidan C. Manning, Jenna M. Lentini, Jonathan Howard, Felix Dalwigk, Reza Maroofian, Stephanie Efthymiou, Patricia Chan, Sergei I. Eliseev, Zi Yang, Hayley Chang, Ehsan Ghayoor Karimiani, Behnoosh Bakhshoodeh, Henry Houlden, Stefanie M. Kaiser, Todd M. Lowe, Dragony Fu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724014438
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