Genetic polymorphisms (FTO rs9939609 and TMEM18 rs6548238), adipokines (leptin and adiponectin) and adiposity in children and adolescents with asthma
Objective: To describe independent factors related to the interaction of FTO rs9939609, TMEM18 rs6548238, leptin, and adiponectin in children/adolescents with asthma, under the influence of obesity. Methods: The authors performed a cross-sectional study with 57 children/adolescents, ages 8–19 years,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Jornal de Pediatria |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0021755724000974 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841560548935729152 |
|---|---|
| author | Marta Evangelho Machado Luis C. Porto Jeane S. Nogueira Clemax C. Sant´Anna José R. Lapa e Silva |
| author_facet | Marta Evangelho Machado Luis C. Porto Jeane S. Nogueira Clemax C. Sant´Anna José R. Lapa e Silva |
| author_sort | Marta Evangelho Machado |
| collection | DOAJ |
| description | Objective: To describe independent factors related to the interaction of FTO rs9939609, TMEM18 rs6548238, leptin, and adiponectin in children/adolescents with asthma, under the influence of obesity. Methods: The authors performed a cross-sectional study with 57 children/adolescents, ages 8–19 years, at a tertiary hospital, from 2017 to 2018. Participants were classified by nutritional status, performed spirometry with a bronchodilator test and completed an asthma questionnaire, higher scores indicated more asthma symptoms. Two asthma groups were formed: Group 1(G1)-normal-weight; Group 2(G2)-overweight/obese. Serum was collected for adipokines (n = 32) and genetic polymorphisms (n = 53) dosages. Results: Age and body mass index (BMI) correlated directly in normal-weight (p = 0.009) and obese participants (p = 0.004). Girls reported more asthma complaints (p = 0.044). Participants with negative bronchodilator responses presented lower BMI (14.55–17.16) than responders (19.4–26.84) (p = 0.049). Leptin dosages are related directly to BMI (5,34–40 ng/ml in obese × 0,54–42 ng/ml in nonobese) (p = 0.003). Levels were high in girls (4.78–17.55 µg/ml) (p = 0.029) and low in nonobese boys (0.54–6.92 µg/ml) (p = 0.006). In obese, low leptin levels (< 10 ng/ml) were found in small airway dysfunction carriers (p = 0.025); elevated adiponectin (> 5 µg/ml) correlated with FEV1/FVC > 80 % (p = 0.035) and positive bronchodilator tests (8.84–13 µg/ml) (p = 0.039); and FTO A allele correlated with low adiponectin 0–8.84 µg/ml (p = 0.021) and low FEV1/FVC (46 %-88 %) (p = 0.023). Conclusion: BMI correlated directly with age and leptin levels. Obese participants presented high serum levels of leptin and FTO A allele correlated with low FEV1/FVC. Larger cohorts are necessary for better elucidation of the role of adipokines and polymorphisms in the pathophysiology of asthma and obesity. |
| format | Article |
| id | doaj-art-3fa26d0ccccc414b8d2446ab0b34b700 |
| institution | Kabale University |
| issn | 0021-7557 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj-art-3fa26d0ccccc414b8d2446ab0b34b7002025-01-04T04:55:47ZengElsevierJornal de Pediatria0021-75572025-01-0110118995Genetic polymorphisms (FTO rs9939609 and TMEM18 rs6548238), adipokines (leptin and adiponectin) and adiposity in children and adolescents with asthmaMarta Evangelho Machado0Luis C. Porto1Jeane S. Nogueira2Clemax C. Sant´Anna3José R. Lapa e Silva4Universidade Federal do Rio de Janeiro (UFRJ), Programa de Pós-graduação em Clínica Médica (PPGCM - HU), Rio de Janeiro, RJ, Brazil; Fundação Técnico-Educacional Souza Marques, Departamento de Pediatria – Pólo Itanhangá, Rio de Janeiro, RJ, Brazil; Corresponding author.Universidade do Estado do Rio de Janeiro (UERJ), Laboratório de Histocompatibilidade e Criopreservação (HLA - PPC), Rio de Janeiro, RJ, BrazilUniversidade do Estado do Rio de Janeiro (UERJ), Laboratório de Histocompatibilidade e Criopreservação (HLA - PPC), Rio de Janeiro, RJ, BrazilUniversidade Federal do Rio de Janeiro (UFRJ), Programa de Pós-graduação em Clínica Médica (PPGCM - HU), Rio de Janeiro, RJ, BrazilUniversidade Federal do Rio de Janeiro (UFRJ), Programa de Pós-graduação em Clínica Médica (PPGCM - HU), Rio de Janeiro, RJ, BrazilObjective: To describe independent factors related to the interaction of FTO rs9939609, TMEM18 rs6548238, leptin, and adiponectin in children/adolescents with asthma, under the influence of obesity. Methods: The authors performed a cross-sectional study with 57 children/adolescents, ages 8–19 years, at a tertiary hospital, from 2017 to 2018. Participants were classified by nutritional status, performed spirometry with a bronchodilator test and completed an asthma questionnaire, higher scores indicated more asthma symptoms. Two asthma groups were formed: Group 1(G1)-normal-weight; Group 2(G2)-overweight/obese. Serum was collected for adipokines (n = 32) and genetic polymorphisms (n = 53) dosages. Results: Age and body mass index (BMI) correlated directly in normal-weight (p = 0.009) and obese participants (p = 0.004). Girls reported more asthma complaints (p = 0.044). Participants with negative bronchodilator responses presented lower BMI (14.55–17.16) than responders (19.4–26.84) (p = 0.049). Leptin dosages are related directly to BMI (5,34–40 ng/ml in obese × 0,54–42 ng/ml in nonobese) (p = 0.003). Levels were high in girls (4.78–17.55 µg/ml) (p = 0.029) and low in nonobese boys (0.54–6.92 µg/ml) (p = 0.006). In obese, low leptin levels (< 10 ng/ml) were found in small airway dysfunction carriers (p = 0.025); elevated adiponectin (> 5 µg/ml) correlated with FEV1/FVC > 80 % (p = 0.035) and positive bronchodilator tests (8.84–13 µg/ml) (p = 0.039); and FTO A allele correlated with low adiponectin 0–8.84 µg/ml (p = 0.021) and low FEV1/FVC (46 %-88 %) (p = 0.023). Conclusion: BMI correlated directly with age and leptin levels. Obese participants presented high serum levels of leptin and FTO A allele correlated with low FEV1/FVC. Larger cohorts are necessary for better elucidation of the role of adipokines and polymorphisms in the pathophysiology of asthma and obesity.http://www.sciencedirect.com/science/article/pii/S0021755724000974Single nucleotide polymorphismGeneAlleleObesityOverweightAsthma |
| spellingShingle | Marta Evangelho Machado Luis C. Porto Jeane S. Nogueira Clemax C. Sant´Anna José R. Lapa e Silva Genetic polymorphisms (FTO rs9939609 and TMEM18 rs6548238), adipokines (leptin and adiponectin) and adiposity in children and adolescents with asthma Jornal de Pediatria Single nucleotide polymorphism Gene Allele Obesity Overweight Asthma |
| title | Genetic polymorphisms (FTO rs9939609 and TMEM18 rs6548238), adipokines (leptin and adiponectin) and adiposity in children and adolescents with asthma |
| title_full | Genetic polymorphisms (FTO rs9939609 and TMEM18 rs6548238), adipokines (leptin and adiponectin) and adiposity in children and adolescents with asthma |
| title_fullStr | Genetic polymorphisms (FTO rs9939609 and TMEM18 rs6548238), adipokines (leptin and adiponectin) and adiposity in children and adolescents with asthma |
| title_full_unstemmed | Genetic polymorphisms (FTO rs9939609 and TMEM18 rs6548238), adipokines (leptin and adiponectin) and adiposity in children and adolescents with asthma |
| title_short | Genetic polymorphisms (FTO rs9939609 and TMEM18 rs6548238), adipokines (leptin and adiponectin) and adiposity in children and adolescents with asthma |
| title_sort | genetic polymorphisms fto rs9939609 and tmem18 rs6548238 adipokines leptin and adiponectin and adiposity in children and adolescents with asthma |
| topic | Single nucleotide polymorphism Gene Allele Obesity Overweight Asthma |
| url | http://www.sciencedirect.com/science/article/pii/S0021755724000974 |
| work_keys_str_mv | AT martaevangelhomachado geneticpolymorphismsftors9939609andtmem18rs6548238adipokinesleptinandadiponectinandadiposityinchildrenandadolescentswithasthma AT luiscporto geneticpolymorphismsftors9939609andtmem18rs6548238adipokinesleptinandadiponectinandadiposityinchildrenandadolescentswithasthma AT jeanesnogueira geneticpolymorphismsftors9939609andtmem18rs6548238adipokinesleptinandadiponectinandadiposityinchildrenandadolescentswithasthma AT clemaxcsantanna geneticpolymorphismsftors9939609andtmem18rs6548238adipokinesleptinandadiponectinandadiposityinchildrenandadolescentswithasthma AT joserlapaesilva geneticpolymorphismsftors9939609andtmem18rs6548238adipokinesleptinandadiponectinandadiposityinchildrenandadolescentswithasthma |