Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila melanogaster

Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila melanogaster

Abstract Aberration of mitochondrial function is a shared feature of many human pathologies, characterised by changes in metabolic flux, cellular energetics, morphology, composition, and dynamics of the mitochondrial network. While some of these changes serve as compensatory mechanisms to maintain c...

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Main Authors: Najla El Fissi, Florian A. Rosenberger, Kai Chang, Alissa Wilhalm, Tom Barton-Owen, Fynn M. Hansen, Zoe Golder, David Alsina, Anna Wedell, Matthias Mann, Patrick F. Chinnery, Christoph Freyer, Anna Wredenberg
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55559-2
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https://doi.org/10.1038/s41467-024-55559-2

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